Virulence Factors in Hypervirulent Klebsiella pneumoniae

Frontiers in Microbiology

卷:12

Jie Zhu¹  Tao Wang¹  Hong Du¹  Liang Chen² 

[1] Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, China;

[2] Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, NJ, United States;

[3] Hackensack Meridian Health Center for Discovery and Innovation, Nutley, NJ, United States;

关键词: Klebsiella pneumoniae;    hypermucoviscous;    capsule;    siderophores;    virulence factors;    hypervirulence;   

DOI  :  10.3389/fmicb.2021.642484

来源: DOAJ

【 摘 要 】

Hypervirulent Klebsiella pneumoniae (hvKP) has spread globally since first described in the Asian Pacific Rim. It is an invasive variant that differs from the classical K. pneumoniae (cKP), with hypermucoviscosity and hypervirulence, causing community-acquired infections, including pyogenic liver abscess, pneumonia, meningitis, and endophthalmitis. It utilizes a battery of virulence factors for survival and pathogenesis, such as capsule, siderophores, lipopolysaccharide, fimbriae, outer membrane proteins, and type 6 secretion system, of which the former two are dominant. This review summarizes these hvKP-associated virulence factors in order to understand its molecular pathogenesis and shed light on new strategies to improve the prevention, diagnosis, and treatment of hvKP-causing infection.

【 授权许可】

Unknown