Artemether–lumefantrine treatment failure despite adequate lumefantrine day 7 concentration in a traveller with Plasmodium falciparum malaria after returning from Tanzania

Malaria Journal

卷:11

关键词: Malaria;    P. falciparum;    Artemisinin;    Lumefantrine;    Sensitivity;    non-immune;   

DOI  :  10.1186/1475-2875-11-176

来源: DOAJ

【 摘 要 】

Abstract

Artemether-lumefantrine is currently first-line therapy of Plasmodium falciparum malaria in many countries. This report describes a treatment failure despite adequate drug concentrations in a traveller returning from sub-Saharan Africa. Genotyping confirmed recrudescence and suggested reduced sensitivity. Potential sub-optimal effect of artemether-lumefantrine highlights the need to follow non-immune individuals the weeks after treatment.

【 授权许可】

Unknown