Magnetically triggered drug release from nanoparticles and its applications in anti-tumor treatment

Drug Delivery

卷:24

Hugh D. C. Smyth¹  Jiashuo Zhang²  Shengnan Tan²  Qin Yang³  Qiudong Wang³  Xin Hua³  Wanjiang Zhang³  Zhimin Dong⁴ 

[1] College of Pharmacy, The University of Texas at Austin;

[2] College of Wildlife Resources, College of Life Science, Northeast Forestry University;

[3] State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences;

[4] Tianjin Animal Science and Veterinary Research Institute;

关键词: magnetic nanoparticles;    oscillating magnetic field;    controlled release;    doxorubicin;   

DOI  :  10.1080/10717544.2016.1256001

来源: DOAJ

【 摘 要 】

The objective of this study was to describe the magnetic nanoparticle–drug conjugates for improved control of drug delivery and drug release. The widely used anticancer agent Doxorubicin (DOX) was successfully conjugated via amine groups to the carboxylic functional groups coating magnetic nanoparticles (fluidMAG-CMX). Following purification of the nanoparticles, the conjugation of DOX on fluidMAG-CMX was confirmed using FTIR spectroscopy and confocal microscopy. The observed drug loading capacity of DOX was 22.3%. Studies of magnetically triggered release were performed under an oscillating magnetic field (OMF). DOX exhibited a significant release percentage of 70% under an OMF, as compared with the release in enzyme. A magnetic field turn-on and turn-off experiment was also conducted to confirm the control of drug release using this triggered system. In vivo experiments indicated that the tumor-inhibitory rate of CMX–DOX NPs under a magnetic field was higher than the other control groups. According to the toxicity assessments, CMX–DOX NPs were not noticeably toxic to mice at our tested dose.

【 授权许可】

Unknown