Iron Oxide Nanoparticles for Magnetically-Guided and Magnetically-Responsive Drug Delivery

International Journal of Molecular Sciences

Joan Estelrich²  Elvira Escribano¹  Josep Queralt³  Maria Antònia Busquets² 

[1] Departament de Farmàcia i Tecnologia Farmacèutica, Facultat de Farmàcia, Institut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona, 08028 Barcelona, Catalonia, Spain; E-Mail:;Departament de Fisicoquímica; Facultat de Farmàcia; Institut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona, 08028 Barcelona, Catalonia, Spain; E-Mail:;Departament de Fisiologia, Facultat de Farmàcia; Institut de Nanociència i Nanotecnologia (IN2UB), Universitat de Barcelona, 08028 Barcelona, Catalonia, Spain; E-Mail:

关键词: magnetic nanoparticles;    magnetoliposomes;    liposomes;    gels;    nanotechnology;    controlled release;    chemotherapy;   

DOI  :  10.3390/ijms16048070

来源: mdpi

【 摘 要 】

In this review, we discuss the recent advances in and problems with the use of magnetically-guided and magnetically-responsive nanoparticles in drug delivery and magnetofection. In magnetically-guided nanoparticles, a constant external magnetic field is used to transport magnetic nanoparticles loaded with drugs to a specific site within the body or to increase the transfection capacity. Magnetofection is the delivery of nucleic acids under the influence of a magnetic field acting on nucleic acid vectors that are associated with magnetic nanoparticles. In magnetically-responsive nanoparticles, magnetic nanoparticles are encapsulated or embedded in a larger colloidal structure that carries a drug. In this last case, an alternating magnetic field can modify the structure of the colloid, thereby providing spatial and temporal control over drug release.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.