Characterization and Pilot Human Trial of Dedicated Breast Ring Positron Emission Tomography (BRPET) System

Instruments

卷:5

Patrick M. Dillon¹  Annie K. Kogler²  Stanislaw Majewski³  Luke Lancaster³  Mark B. Williams³  Heather R. Peppard³  Andrew M. Polemi³  Patrice K. Rehm³  Alexander V. Stolin⁴ 

[1] Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA;

[2] Department of Physics, University of Virginia, Charlottesville, VA 22904, USA;

[3] Department of Radiology and Medical Imaging, University of Virginia, Charlottesville, VA 22908, USA;

[4] Department of Radiology, West Virginia University, Morgantown, WV 26506, USA;

关键词: dedicated breast PET;    performance evaluation;    PET instrumentation;    breast imaging;   

DOI  :  10.3390/instruments5030030

来源: DOAJ

【 摘 要 】

We describe the design and performance of BRPET, a novel dedicated breast PET (dbPET) scanner designed to maximize visualization of posterior regions of the breast. BRPET uses prone imaging geometry and a 12-module detector ring built from pixelated LYSO crystals coupled to position sensitive photomultiplier tubes (PSPMTs). Optical coupling via slanted plastic fiber optic light guides permits partial insertion of the crystals into the exam table’s breast aperture. Image quality testing procedures were adapted from the NEMA NU4-2008 protocol. Two additional phantom tests quantified the posterior extent of the usable volume of view (VoV). BRPET axial, radial, and tangential FWHM spatial resolutions at the isocenter were 1.8, 1.7, and 1.9 mm, respectively. The peak absolute system sensitivity was 0.97% using an energy window of 460–562 keV. The peak noise equivalent counting rate was 5.33 kcps at 21.6 MBq. The scanner VoV extends to within ~6 mm of the plane defining the location of the chest wall. A pilot human study (n = 10) compared the diagnostic performance of FDG-BRPET to that of contrast enhanced MRI (CEMRI), with biopsy as ground truth. Averaged over three expert human observers, the sensitivity/specificity for BRPET was 0.93/1.0, compared to 1.0/0.25 for CEMRI.

【 授权许可】

Unknown