Nanostructures for the Inhibition of Viral Infections

Molecules

卷:20

Rabah Boukherroub¹  Sabine Szunerits¹  Manakamana Khanal¹  Alexandre Barras¹  Quentin Pagneux¹ 

[1] Institute of Electronics, Microelectronics and Nanotechnology (IEMN), UMR 8520 CNRS,Lille1 University, Avenue Poincaré—BP 60069, 59652 Villeneuve d\'Ascq, France;

关键词: viral infections;    antiviral therapy;    nanomaterials;   

DOI  :  10.3390/molecules200814051

来源: DOAJ

【 摘 要 】

Multivalent interactions are omnipresent in biology and confer biological systems with dramatically enhanced affinities towards different receptors. Such multivalent binding interactions have lately been considered for the development of new therapeutic strategies against bacterial and viral infections. Multivalent polymers, dendrimers, and liposomeshave successfully targeted pathogenic interactions. While a high synthetic effort was often needed for the development of such therapeutics, the integration of multiple ligands onto nanostructures turned to be a viable alternative. Particles modified with multiple ligands have the additional advantage of creating a high local concentration of binding molecules. This review article will summarize the different nanoparticle-based approaches currently available for the treatment of viral infections.

【 授权许可】

Unknown