Nanostructures for the Inhibition of Viral Infections

Molecules

Sabine Szunerits¹  Alexandre Barras²  Manakamana Khanal²  Quentin Pagneux²  Rabah Boukherroub² 

[1] Institute of Electronics, Microelectronics and Nanotechnology (IEMN), UMR 8520 CNRS, Lille1 University, Avenue Poincaré—BP 60069, 59652 Villeneuve d’Ascq, France;

关键词: viral infections;    antiviral therapy;    nanomaterials;   

DOI  :  10.3390/molecules200814051

来源: mdpi

【 摘 要 】

Multivalent interactions are omnipresent in biology and confer biological systems with dramatically enhanced affinities towards different receptors. Such multivalent binding interactions have lately been considered for the development of new therapeutic strategies against bacterial and viral infections. Multivalent polymers, dendrimers, and liposomes have successfully targeted pathogenic interactions. While a high synthetic effort was often needed for the development of such therapeutics, the integration of multiple ligands onto nanostructures turned to be a viable alternative. Particles modified with multiple ligands have the additional advantage of creating a high local concentration of binding molecules. This review article will summarize the different nanoparticle-based approaches currently available for the treatment of viral infections.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.