Viral Sepsis in Children

Frontiers in Pediatrics

Neha Gupta¹ 

关键词: viral sepsis;    sepsis;    viral infections;    viral coinfections;    secondary bacterial infections;    pediatric;    children;   

DOI  :  10.3389/fped.2018.00252

学科分类：儿科学

来源: Frontiers

【 摘 要 】

Sepsis in children is typically presumed to be bacterial in origin until proven otherwise, but frequently bacterial cultures ultimately return negative. Although viruses may be important causative agents of culture-negative sepsis worldwide, the incidence, disease burden and mortality of viral-induced sepsis is poorly elucidated. Consideration of viral sepsis is critical as its recognition carries implications on appropriate use of antibacterial agents, infection control measures, and, in some cases, specific, time-sensitive antiviral therapies. This review outlines our current understanding of viral sepsis in children and addresses its epidemiology and pathophysiology, including pathogen-host interaction during active infection. Clinical manifestation, diagnostic testing, and management options unique to viral infections will be outlined.

【 授权许可】

CC BY