mSphere of Influence: Synthetic Biology of Natural Product Biosynthesis

mSphere

卷:5

Mark C. Walker¹ 

[1] Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico, USA;

关键词: biosynthesis;    metabolic engineering;    natural product;   

DOI  :  10.1128/mSphere.00954-19

来源: DOAJ

【 摘 要 】

ABSTRACT Mark Walker studies the biosynthesis and engineering of bacterial natural products with the long-term goal of identifying new antibiotic compounds. In this mSphere of Influence, he reflects on how “Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A” by K. Yamanaka, K. A. Reynolds, R. D. Kersten, K. S. Ryan, et al. (Proc Natl Acad Sci USA 111:1957–1962, 2014, https://doi.org/10.1073/pnas.1319584111) impacted his thinking on using synthetic biology approaches to study natural product biosynthesis.

【 授权许可】

Unknown