Microbial Cell Factories for Green Production of Vitamins

Frontiers in Bioengineering and Biotechnology

Linxia Liu²  Zhaoxia Jin³  Yanyan Wang⁴  Dawei Zhang⁵ 

[1] Key Laboratory of Systems Microbial Biotechnology, Chinese Academy of Sciences, Tianjin, China;National Technology Innovation Center of Synthetic Biology, Tianjin, China;School of Biological Engineering, Dalian Polytechnic University, Dalian, China;Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China;University of Chinese Academy of Sciences, Beijing, China;

关键词: vitamins;    metabolic engineering;    microbial cell factory;    chemical synthesis;    biosynthesis;   

DOI  :  10.3389/fbioe.2021.661562

来源: DOAJ

【 摘 要 】

Vitamins are a group of essential nutrients that are necessary to maintain normal metabolic activities and optimal health. There are wide applications of different vitamins in food, cosmetics, feed, medicine, and other areas. The increase in the global demand for vitamins has inspired great interest in novel production strategies. Chemical synthesis methods often require high temperatures or pressurized reactors and use non-renewable chemicals or toxic solvents that cause product safety concerns, pollution, and hazardous waste. Microbial cell factories for the production of vitamins are green and sustainable from both environmental and economic standpoints. In this review, we summarized the vitamins which can potentially be produced using microbial cell factories or are already being produced in commercial fermentation processes. They include water-soluble vitamins (vitamin B complex and vitamin C) as well as fat-soluble vitamins (vitamin A/D/E and vitamin K). Furthermore, metabolic engineering is discussed to provide a reference for the construction of microbial cell factories. We also highlight the current state and problems encountered in the fermentative production of vitamins.

【 授权许可】

Unknown