Anti-inflammatory potential of Quercetin in COVID-19 treatment

Journal of Inflammation

卷:18

Ali Saeedi-Boroujeni¹  Mohammad-Reza Mahmoudian-Sani² 

[1] Department of Immunology, Faculty of Medicine, Ahvaz Jundishapur University of Medical, Sciences;

[2] Thalassemia and Hemoglobinopathy Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences;

关键词: COVID-19;    SARS-CoV-2;    Quercetin;    NLRP3 inflammasome;    TXNIP;    SIRT1;   

DOI  :  10.1186/s12950-021-00268-6

来源: DOAJ

【 摘 要 】

Abstract SARS-CoV-2 is a betacoronavirus causing severe inflammatory pneumonia, so that excessive inflammation is considered a risk factor for the disease. According to reports, cytokine storm is strongly responsible for death in such patients. Some of the consequences of severe inflammation and cytokine storms include acute respiratory distress syndrome, acute lung injury, and multiple organ dysfunction syndromes. Phylogenetic findings show more similarity of the SARS-CoV-2 virus with bat coronaviruses, and less with SARS-CoV. Quercetin is a carbohydrate-free flavonoid that is the most abundant flavonoid in vegetables and fruits and has been the most studied to determine the biological effects of flavonoids. Inflammasomes are cytosolic multi-protein complexes assembling in response to cytosolic PAMP and DAMPs, whose function is to generate active forms of cytokines IL-1β and IL-18. Activation or inhibition of the NLRP3 inflammasome is affected by regulators such as TXNIP, SIRT1 and NRF2. Quercetin suppresses the NLRP3 inflammasome by affecting these regulators. Quercetin, as an anti-inflammatory, antioxidant, analgesic and inflammatory compound, is probably a potential treatment for severe inflammation and one of the main life-threatening conditions in patients with COVID-19.

【 授权许可】

Unknown