Impaired recognition of disgust in amyotrophic lateral sclerosis is related to basal ganglia involvement

NeuroImage: Clinical

卷:32

Vincenzo Silani¹  Elisa Canu²  Massimo Filippi³  Federica Agosta³  Maria Antonietta Magno⁴  Veronica Castelnovo⁴  Silvia Basaia⁴  Nilo Riva⁴  Barbara Poletti⁵ 

[1] Neurorehabilitation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy;

[2] Vita-Salute San Raffaele University, Milan, Italy;

[3] Department of Neurology and Laboratory of Neuroscience, IRCCS Istituto Auxologico Italiano, Milan, Italy;

[4] Neuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy;

[5] Neurology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy;

关键词: Amyotrophic lateral sclerosis;    Basal ganglia;    Disgust;    Emotions;    MRI;   

DOI  :  

来源: DOAJ

【 摘 要 】

In the present study we investigated emotion recognition in pure motor amyotrophic lateral sclerosis (ALS) patients and its relationship with the integrity of basal ganglia, hippocampus and amygdala. Twenty ALS patients without either cognitive or behavioural impairment, and 52 matched healthy controls performed a neuropsychological assessment including the Comprehensive Affect Testing System (CATS) investigating emotion recognition. All participants underwent also a 3T brain MRI. Volumes of basal ganglia, hippocampus and amygdala bilaterally were measured using FIRST in FSL. Sociodemographic, cognitive and MRI data were compared between groups. In ALS patients, correlations between CATS significant findings, brain volumes, cognition, mood and behaviour were explored. ALS patients showed altered performances at the CATS total score and, among the investigated emotions, patients were significantly less able to recognize disgust compared with controls. No brain volumetric differences were observed between groups. In ALS patients, a lower performance in disgust recognition was related with a reduced volume of the left pallidum and a lower performance on the Edinburgh Cognitive and Behavioural ALS Screen. Cognitively/behaviourally unimpaired ALS patients showed impaired disgust recognition, which was associated with pallidum volume. The association with cognitive alterations may suggest impaired disgust recognition as an early marker of cognitive decline.

【 授权许可】

Unknown