Metabolic Imaging of Deep Brain Stimulation in Meige Syndrome

Frontiers in Aging Neuroscience

卷:14

Ruen Liu¹  Hu Ding¹  Jiayu Liu¹  Yuan Li²  Qian Wang²  Lei Li³ 

[1] Department of Neurosurgery, Peking University People’s Hospital, Beijing, China;

[2] Department of Nuclear Medicine, Peking University People’s Hospital, Beijing, China;

[3] Department of Nuclear Medicine, Zhuhai People’s Hospital (Zhuhai Hospital Affiliated With Jinan University), Zhuhai, China;

关键词: positron emission tomography;    meige syndrome;    deep brain stimulation;    subthalamic nucleus;    glucose metabolism;   

DOI  :  10.3389/fnagi.2022.848100

来源: DOAJ

【 摘 要 】

ObjectivesThe subthalamic nucleus (STN) has been shown to be a safe and effective deep brain stimulation (DBS) surgical target for the treatment of Meige syndrome. The aim of this study was to compare changes in brain metabolism before and 6 months after STN-DBS surgery.MethodsTwenty-five patients with primary Meige syndrome underwent motor function assessment, including the Burke–Fahn–Marsden Dystonia Rating Scale movement (BFMDRS-M) and disability subscale (BFMDRS-D) and positron emission tomography with an 18[F]-fluorodeoxyglucose scan before and 6 months after STN-DBS surgery. For the voxelwise metabolic change assessment, the p-value was controlled for multiple comparisons using the familywise error rate.ResultsThere was a significant decrease in BFMDRS-M scores 6 months after STN-DBS, from 10.02 ± 3.99 to 4.00 ± 2.69 (p < 0.001). The BFMDRS-D scores also decreased significantly from 4.52 ± 2.90 to 0.64 ± 1.29 (p < 0.001). In the left hemisphere, hypermetabolism was found in the occipital lobe, superior parietal gyrus, postcentral gyrus and thalamus. In the right hemisphere, hypermetabolism was found in the lentiform nucleus, precuneus and precentral gyrus in patients with Meige syndrome receiving DBS. In addition, the bilateral inferior temporal gyrus and middle frontal gyrus exhibited glucose hypermetabolism.ConclusionOur findings indicate that STN-DBS has a significant effect on metabolic level in the brain, which may be an important mechanism for the treatment of Meige syndrome using STN-DBS.

【 授权许可】

Unknown