Noninvasive Urine-Based Tests to Diagnose or Detect Recurrence of Bladder Cancer

Cancers

卷:13

Rémy Pedeux¹  Marine Charpentier¹  Charly Gutierrez¹  Thierry Guillaudeux¹  Grégory Verhoest² 

[1] COSS (Chemistry Oncogenesis Stress Signaling)—UMR_S 1242, University of Rennes, INSERM, CLCC Eugène Marquis, F-35000 Rennes, France;

[2] Department of Urology, CHU RENNES, Rue Henri le Guilloux, 35033 Rennes, France;

关键词: bladder cancer;    diagnostic;    non-invasive;    liquid biopsy;    cytology;    urine;   

DOI  :  10.3390/cancers13071650

来源: DOAJ

【 摘 要 】

Liquid biopsies are increasingly used for the diagnosis and follow-up of cancer patients. Urine is a body fluid that can be used to detect cancers and others diseases. It is noninvasive and easy to collect. To detect Bladder Cancer (BC), cytology is the first assay used. It is an effective way to detect high grade BC but has a high rate of equivocal results, especially for low grade BC. Furthermore, cystoscopy is used to confirm cytology results and to determine cancer status. Cystoscopy is also effective but highly invasive, and not well accepted by patients, especially for BC follow-up. In this review we survey the numerous assays recently developed in order to diagnose BC at an early stage, and to facilitate the follow-up of patients. We discuss their effectiveness, ease of use, and applications. Finally, we discuss assays that, in the future, could improve the diagnosis and management of BC patients.

【 授权许可】

Unknown