期刊论文详细信息
Frontiers in Immunology | 卷:8 |
Sugar or Fat?—Metabolic Requirements for Immunity to Viral Infections | |
Suzanne M. Crowe2  Clovis Steve Palmer3  Man kit Sam Lee4  Andrew J. Murphy4  Clair M. Gardiner5  David K. Finlay5  Shomyseh Sanjabi6  Hesham M. Shehata6  | |
[1] Centre for Biomedical Research, Burnet Institute, Melbourne, VIC, Australia; | |
[2] Department of Infectious Diseases, Monash University, Melbourne, VIC, Australia; | |
[3] Department of Microbiology and Immunology, University of Melbourne, Melbourne, VIC, Australia; | |
[4] Haematopoiesis and Leukocyte Biology, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia; | |
[5] School of Biochemistry and Immunology, Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin, Ireland; | |
[6] Virology and Immunology, Gladstone Institutes, San Francisco, CA, United States; | |
关键词: immunometabolism; glycolysis; mTOR; HIV; T cells; viral infection; | |
DOI : 10.3389/fimmu.2017.01311 | |
来源: DOAJ |
【 摘 要 】
The realization that an intricate link exists between the metabolic state of immune cells and the nature of the elicited immune responses has brought a dramatic evolution to the field of immunology. We will focus on how metabolic reprogramming through the use of glycolysis and fatty-acid oxidation (sugar or fat) regulates the capacity of immune cells to mount robust and effective immune responses. We will also discuss how fine-tuning sugar and fat metabolism may be exploited as a novel immunotherapeutic strategy to fight viral infections or improve vaccine efficacy.
【 授权许可】
Unknown