Sugar or Fat?—Metabolic Requirements for Immunity to Viral Infections

Frontiers in Immunology

卷:8

Suzanne M. Crowe²  Clovis Steve Palmer³  Man kit Sam Lee⁴  Andrew J. Murphy⁴  Clair M. Gardiner⁵  David K. Finlay⁵  Shomyseh Sanjabi⁶  Hesham M. Shehata⁶ 

[1] Centre for Biomedical Research, Burnet Institute, Melbourne, VIC, Australia;

[2] Department of Infectious Diseases, Monash University, Melbourne, VIC, Australia;

[3] Department of Microbiology and Immunology, University of Melbourne, Melbourne, VIC, Australia;

[4] Haematopoiesis and Leukocyte Biology, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia;

[5] School of Biochemistry and Immunology, Trinity College Dublin, Trinity Biomedical Sciences Institute, Dublin, Ireland;

[6] Virology and Immunology, Gladstone Institutes, San Francisco, CA, United States;

关键词: immunometabolism;    glycolysis;    mTOR;    HIV;    T cells;    viral infection;   

DOI  :  10.3389/fimmu.2017.01311

来源: DOAJ

【 摘 要 】

The realization that an intricate link exists between the metabolic state of immune cells and the nature of the elicited immune responses has brought a dramatic evolution to the field of immunology. We will focus on how metabolic reprogramming through the use of glycolysis and fatty-acid oxidation (sugar or fat) regulates the capacity of immune cells to mount robust and effective immune responses. We will also discuss how fine-tuning sugar and fat metabolism may be exploited as a novel immunotherapeutic strategy to fight viral infections or improve vaccine efficacy.

【 授权许可】

Unknown