Endocrine‐disrupting chemicals and male reproductive health

Reproductive Medicine and Biology

卷:19

Suks Minhas¹  Aditi Sharma²  Richard W. K. Brocklesby²  Charlotte Caves²  Channa N. Jayasena²  Josephine Mollier² 

[1] Imperial Centre for Andrology Imperial College Healthcare NHS Trust London UK;

[2] Section of Investigative Medicine Faculty of Medicine Imperial College London London UK;

关键词: endocrine‐disrupting chemicals;    environmental;    male infertility;    semen quality;    sperm;   

DOI  :  10.1002/rmb2.12326

来源: DOAJ

【 摘 要 】

Abstract Background A number of different types of endocrine‐disrupting chemicals (EDCs) including bisphenol A, phthalates, pesticides, and other environmental chemicals have been shown to adversely impact upon male reproductive health. Understanding the potential effects of EDCs on male reproductive health may enable the development of novel treatments and early prevention of the effects of EDCs on male infertility and their potential long‐term sequelae. This review critically evaluates the research performed in this area and explores potential harmful effects of EDCs in animals and humans, including the possibility of trans‐generational transmission. Methods A literature review was conducted using electronic databases using the following terms: ‘endocrine disrupt*’ OR ‘endocrine disruptors’ OR ‘endocrine disruptor chemicals’ OR ‘EDC’ AND ‘sperm*’ OR ‘spermatozoa’ OR ‘spermatozoon’ OR ‘male reproductive health’ OR’ male fertility’. Main findings Several studies have shown that EDCs have a variety of pathophysiological effects. These include failure of spermatogenesis, embryonic development, the association with testicular cancer, and long‐term metabolic effects. Conclusions Several studies observe correlations between chemical doses and at least one sperm parameter; however, such correlations are sometimes inconsistent between different studies. Mechanisms through which EDCs exert their pathophysiological effects have not yet been fully elucidated in human studies.

【 授权许可】

Unknown