Body composition and pulmonary function in Cystic Fibrosis

Frontiers in Pediatrics

卷:2

Ronald C Rubenstein¹  Babette S Zemel¹  Andrea eKelly¹  Saba eSheikh¹  Virginia A Stallings¹ 

[1] The Children's Hospital of Philadelphia;

关键词: Body Mass Index;    Lean Body Mass;    Fat Mass Index;    Lean Body Mass Index;    Pancreatic Insufficient;   

DOI  :  10.3389/fped.2014.00033

来源: DOAJ

【 摘 要 】

Background: Lower body mass index (BMI) is associated with worse pulmonary function in cystic fibrosis (CF).
Hypothesis: Lean body mass (LBM) is more strongly associated with pulmonary function than BMI is.
Methods: Anthropometrics, body composition by dual x-ray absorptiometry, and pulmonary function were determined in pancreatic insufficient CF (PI-CF) youth. Sex and age-adjusted Z-scores (BMI-Z, LBMI-Z, FMI-Z) were generated for CF and controls. 1) Associations of BMI-Z with LBMI-Z and FMI-Z and 2) age-adjusted associations of BMI-Z, LBMI-Z, and FMI-Z with FEV1%-predicted were tested.
Results: 208 PI-CF subjects had lower BMI-Z, LBMI-Z, FMI-Z compared to 390 controls. BMI-Z was associated with lower LBMI-Z (p< 0.0001) in PI-CF.In females, LBMI-Z and BMI-Z were positively associated with FEV1%-predicted; this relationship did not persist for FMI-Z after adjustment for LBMI-Z.In males, only LBMI-Z and BMI-Z were associated with FEV1%-predicted.
Conclusions: In PI-CF youth, deficits in LBM were apparent. At lower BMI percentiles, BMI may not accurately depict LBM in PI-CF. In under-nourished PI-CF youth this preservation of FM in preference to LBM is relevant since LBMI-Z, but not FMI-Z, is positively associated with FEV1%-predicted. LBMI is more strongly associated with lung function compared to BMI, especially in the undernourished child and adolescent with PI-CF.

【 授权许可】

Unknown