Modifiable risk factors associated with bone deficits in childhood cancer survivors

BMC Pediatrics

Research Article

Joanna L Perkins¹  Pam Goodman²  Wendy Leisenring²  K Scott Baker²  Andrew C Dietz³  Alan R Sinaiko⁴  Julia Steinberger⁴  Anna Petryk⁵  Lynda E Polgreen⁵  Donald R Dengel⁶  Lyn M Steffen⁷ 

[1] Children's Hospitals & Clinics of Minnesota, Minneapolis, MN, USA;Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA;Department of Pediatrics, University of California San Diego and Rady Children's Hospital, San Diego, CA, USA;Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA;Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA;Pediatric Endocrinology, University of Minnesota, East Building Room MB671 2450 Riverside Ave., MN 55454, Minneapolis, USA;School of Kinesiology, University of Minnesota, Minneapolis, MN, USA;School of Public Health, University of Minnesota, Minneapolis, MN, USA;

关键词: Bone Mineral Density;    Lean Body Mass;    Growth Hormone Deficiency;    Screen Time;    Lumbar Spine Bone Mineral Density;   

DOI  :  10.1186/1471-2431-12-40

 received in 2011-09-26, accepted in 2012-03-28,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundTo determine the prevalence and severity of bone deficits in a cohort of childhood cancer survivors (CCS) compared to a healthy sibling control group, and the modifiable factors associated with bone deficits in CCS.MethodsCross-sectional study of bone health in 319 CCS and 208 healthy sibling controls. Bone mineral density (BMD) was measured by dual-energy x-ray absorptiometry (DXA). Generalized estimating equations were used to compare measures between CCS and controls. Among CCS, multivariable logistic regression was used to evaluate odds ratios for BMD Z-score ≤ -1.ResultsAll subjects were younger than 18 years of age. Average time since treatment was 10.1 years (range 4.3 - 17.8 years). CCS were 3.3 times more likely to have whole body BMD Z-score ≤ -1 than controls (95% CI: 1.4-7.8; p = 0.007) and 1.7 times more likely to have lumbar spine BMD Z-score ≤ -1 than controls (95% CI: 1.0-2.7; p = 0.03). Among CCS, hypogonadism, lower lean body mass, higher daily television/computer screen time, lower physical activity, and higher inflammatory marker IL-6, increased the odds of having a BMD Z-score ≤ -1.ConclusionsCCS, less than 18 years of age, have bone deficits compared to a healthy control group. Sedentary lifestyle and inflammation may play a role in bone deficits in CCS. Counseling CCS and their caretakers on decreasing television/computer screen time and increasing activity may improve bone health.

【 授权许可】

CC BY   
© Polgreen et al; licensee BioMed Central Ltd. 2012