The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier

Biomolecules

卷:10

Jean-Claude Martinou¹  Francesco Petrelli¹  Benoît Maillot¹  Joséphine Zangari¹ 

[1] Department of Cell Biology, Faculty of Sciences, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland;

关键词: mitochondria;    mitochondrial pyruvate carrier;    metabolism;    neurodegeneration;    metabolic disorders;    cancer;   

DOI  :  10.3390/biom10071068

来源: DOAJ

【 摘 要 】

Pyruvate, the end product of glycolysis, plays a major role in cell metabolism. Produced in the cytosol, it is oxidized in the mitochondria where it fuels the citric acid cycle and boosts oxidative phosphorylation. Its sole entry point into mitochondria is through the recently identified mitochondrial pyruvate carrier (MPC). In this review, we report the latest findings on the physiology of the MPC and we discuss how a dysfunctional MPC can lead to diverse pathologies, including neurodegenerative diseases, metabolic disorders, and cancer.

【 授权许可】

Unknown