Mucoepidermoid carcinoma of parotid gland and membranous nephropathy – differentiation between sclerosing mucoepidermoid carcinoma with eosinophilia and Kimura’s disease

BMC Nephrology

卷:21

Takahiko Nakajima¹  Hideharu Abe²  Hayato Fujioka³  Koichiro Kinugawa³  Kota Kakeshita³  Tsutomu Koike³  Hidenori Yamazaki³  Teruhiko Imamura³ 

[1] Department of Diagnostic Pathology, University of Toyama;

[2] Department of Otorhinolaryngology, Head & Neck Surgery, University of Toyama;

[3] The Second Department of Internal Medicine, University of Toyama;

关键词: Membranous nephropathy;    Nephrotic syndrome;    Sclerosing mucoepidermoid carcinoma with eosinophilia;   

DOI  :  10.1186/s12882-020-02030-1

来源: DOAJ

【 摘 要 】

Abstract Background When we encounter patients who present with both a neck mass and nephrotic syndrome, both malignancy and Kimura’s disease need to be evaluated as the therapeutic strategies differ vastly between them. Case presentation We present the case of a 27-year-old male patient with neck mass and nephrotic syndrome. The presence of both eosinophilia and elevated immunoglobulin E levels were concerning for Kimura’s disease, which is an allergic syndrome defined by eosinophilic granulomas of neck soft tissue along with peripheral eosinophilia. The eventual final diagnosis, however, was sclerosing mucoepidermoid carcinoma of parotid gland with both eosinophilia and membranous nephropathy. Following the surgical resection of the mass, the nephrotic syndrome completely resolved. Conclusion Detailed histopathological assessments of both the parotid gland and renal tissue were key aspects of the diagnosis and management to exclude Kimura’s disease.

【 授权许可】

Unknown