Bucillamine-Induced Membranous Nephropathy with Crescent Formation in a Patient with Rheumatoid Arthritis: Case Report and Literature Review

Cardiorenal Medicine

Yasuhiko Kita¹  Mayuko Banno¹  Shun Manabe¹  Michiyasu Hatano¹  Teruhiro Fujii¹  Michio Fujiwara¹  Kosaku Nitta¹  Marie Nakano¹ 

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关键词: Crescent formation;    Nephrotic syndrome;    Rheumatoid arthritis;    Membranous nephropathy;    Bucillamine;    Rapidly progressive glomerulonephritis;   

DOI  :  10.1159/000368826

来源: S Karger AG

【 摘 要 】

Bucillamine is a disease-modifying antirheumatic drug that is structurally similar to D-penicillamine. The major renal side effect of bucillamine and D-penicillamine is proteinuria caused by membranous nephropathy (MN). In addition to MN, combined crescent formation has been occasionally reported in D-penicillamine-induced MN, while crescent formation has been rarely reported in bucillamine-treated cases. Here, we describe a 76-year-old female who presented with nephrotic syndrome and rapidly progressive glomerulonephritis. She was receiving bucillamine as initial treatment for recently diagnosed rheumatoid arthritis, and renal biopsy showed MN with crescent formation. To the best of our knowledge, this is the first report of bucillamine-induced MN with crescent formation in the English literature.

【 授权许可】

Unknown