期刊论文详细信息
BMC Infectious Diseases
Schistosoma japonicum infection associated with membranous nephropathy: a case report
Xiang-Chen Xiao1  Zhou-Ning Liao1  Li-Jian Tao1  Zhang-Zhe Peng2  Hong-ling Yin3  Min-Xiang Lei3 
[1] Department of Nephrology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China;Department of Nephrology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China;Hunan Key Lab of Organ Fibrosis, Changsha, China;Department of Nephropathology, Xiangya Hospital, Central South University, Changsha, China;
关键词: Schistosoma japonicum;    Membranous nephropathy;    Nephrotic syndrome;   
DOI  :  10.1186/s12879-022-07092-0
来源: Springer
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【 摘 要 】

BackgroundSchistosomiasis is one of the most contagious parasitic diseases affecting humans; however, glomerular injury is a rare complication mainly described with Schistosoma mansoni infection. We report a case of membranous nephropathy associated with Schistosoma japonicum infection in a Chinese man.Case presentationA 51-year-old Chinese male with a long history of S. japonicum infection presented to the hospital with a slowly progressing severe lower limb edema and foaming urine for over 5 months. Serum S. japonicumantigen test was positive and immunohistochemistry showed that the glomeruli were positive for the antigens. The renal pathologic diagnosis was stage III membranous nephropathy. The patient was treated with glucocorticoid, praziquantel, and an angiotensin-converting enzyme inhibitor. The edema in both lower limbs disappeared within 2 weeks, but his renal function declined progressively and proteinuria persisted after 5 months of therapy.ConclusionsDifferent classes of schistosomal glomerulopathy have completely different clinical manifestation and prognosis. Therefore, efforts should focus on alleviating symptoms, prevention, and early detection. S. japonicumassociated with membranous nephropathy may show a good curative effect and prognosis. However, it is necessary to monitor the renal function in such patients.

【 授权许可】

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