Bioimaging guided pharmaceutical evaluations of nanomedicines for clinical translations

Journal of Nanobiotechnology

卷:20

Abid Hussain¹  Lu Liu²  Xing-Jie Liang²  Yan Huang³  Chenxing Fu⁴  Ruslan G. Tuguntaev⁴  Weisheng Guo⁴  Ying Tao⁴  Haoting Chen⁴ 

[1] Advanced Research Institute of Multidisciplinary Science, School of Life Science, School of Medical Technology (Institute of Engineering Medicine), Key Laboratory of Molecular Medicine and Biotherapy, Key Laboratory of Medical Molecular Science and Pharmaceutics Engineering, Beijing Institute of Technology;

[2] Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China;

[3] Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Nantong University;

[4] Department of Minimally Invasive Interventional Radiology, Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences & the Second Affiliated Hospital, Guangzhou Medical University;

关键词: Nanomedicine;    Biomedical imaging;    Pharmaceutical evaluations;    Physicochemical characteristics;   

DOI  :  10.1186/s12951-022-01451-4

来源: DOAJ

【 摘 要 】

Abstract Nanomedicines (NMs) have emerged as an efficient approach for developing novel treatment strategies against a variety of diseases. Over the past few decades, NM formulations have received great attention, and a large number of studies have been performed in this field. Despite this, only about 60 nano-formulations have received industrial acceptance and are currently available for clinical use. Their in vivo pharmaceutical behavior is considered one of the main challenges and hurdles for the effective clinical translation of NMs, because it is difficult to monitor the pharmaceutic fate of NMs in the biological environment using conventional pharmaceutical evaluations. In this context, non-invasive imaging modalities offer attractive solutions, providing the direct monitoring and quantification of the pharmacokinetic and pharmacodynamic behavior of labeled NMs in a real-time manner. Imaging evaluations have great potential for revealing the relationship between the physicochemical properties of NMs and their pharmaceutical profiles in living subjects. In this review, we introduced imaging techniques that can be used for in vivo NM evaluations. We also provided an overview of various studies on the influence of key parameters on the in vivo pharmaceutical behavior of NMs that had been visualized in a non-invasive and real-time manner. Graphical Abstract

【 授权许可】

Unknown