Intermediate Filaments from Tissue Integrity to Single Molecule Mechanics

Cells

卷:10

Emma J. van Bodegraven¹  Sandrine Etienne-Manneville¹ 

[1] Cell Polarity, Migration and Cancer Unit, Institut Pasteur, UMR3691 CNRS, Equipe Labellisée Ligue Contre le Cancer, F-75015 Paris, France;

关键词: cytoskeleton;    mechanics;    resilience;    rigidity;    stiffness;    elasticity;   

DOI  :  10.3390/cells10081905

来源: DOAJ

【 摘 要 】

Cytoplasmic intermediate filaments (IFs), which together with actin and microtubules form the cytoskeleton, are composed of a large and diverse family of proteins. Efforts to elucidate the molecular mechanisms responsible for IF-associated diseases increasingly point towards a major contribution of IFs to the cell’s ability to adapt, resist and respond to mechanical challenges. From these observations, which echo the impressive resilience of IFs in vitro, we here discuss the role of IFs as master integrators of cell and tissue mechanics. In this review, we summarize our current understanding of the contribution of IFs to cell and tissue mechanics and explain these results in light of recent in vitro studies that have investigated physical properties of single IFs and IF networks. Finally, we highlight how changes in IF gene expression, network assembly dynamics, and post-translational modifications can tune IF properties to adapt cell and tissue mechanics to changing environments.

【 授权许可】

Unknown