Programming the HPA-axis by early life experience: Mechanisms of stress susceptibility and adaptation

Frontiers Research Topics

Rachel Yehuda ; Nikolaos P. Daskalakis

keywords: early life stress;    HPA axis;    Vulnerability;    resilience;    materna;   

Publisher: Frontiers Media SA

Subject:

【 摘 要 】

Experiences during early life program the central nervous- and endocrine-systems with consequences for susceptibility to physical and mental disorders. These programming effects depend on genetic and epigenetic factors, and their outcome leads to an adaptive or maladaptive phenotype to a given later environmental context. This Research Topic focused on the hypothalamus-pituitary-adrenal (HPA)-axis and stress-related phenotypes, and on how HPA-axis programming by the environment precisely occurs. We included original research, mini-review and review papers on a broad range of topics related to HPA-axis programming.

【 授权许可】

CC BY   
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【 图 表 】

Programming the HPA-axis by early life experience_ Mechanisms of stress susceptibility and adaptation.PDF

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