Novel and emerging mutations of SARS-CoV-2: Biomedical implications

Biomedicine & Pharmacotherapy

卷:139

Fatemeh Shafiee¹  Laleh Shariati²  Shaghayegh Haghjooy Javanmard³  Elmira Mohammadi⁴  Behrooz Ataei⁵  Soodeh Hooshmandi⁵  Kiana Shahzamani⁶  Leila Beikmohammadi⁷  Mohammad Mehdi Ranjbar⁸  Shahrzad Ahangarzadeh⁹  Abbas Alibakhshi¹⁰ 

[1] Core Research Facilities, Isfahan University of Medical Sciences, Isfahan, Iran;

[2] Corresponding author.;

[3] Stem Cell and Regenerative Medicine Center of Excellence, Tehran University of Medical Sciences, 14155-6559 Tehran, Iran;

[4] Applied Physiology Research Center, Cardiovascular Research Institute, Department of Physiology, Isfahan University of Medical Sciences, Isfahan, Iran;

[5] Department of Biochemistry, Erasmus University Medical Center, Rotterdam, The Netherlands;

[6] Department of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran;

[7] Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran;

[8] Isfahan Gastroenterology and Hepatology Research Center (lGHRC), Isfahan University of medical sciences, Isfahan, Iran;

[9] Molecular Medicine Research Center, Hamadan University of Medical Sciences, Hamadan, Iran;

[10] Razi Vaccine and Serum Research Institute, Agricultural Research, Education, and Extension Organization (AREEO), Karaj, Iran;

关键词: SARS-CoV-2;    COVID-19;    Mutation;    Genetic variation;    Spike protein;   

DOI  :  

来源: DOAJ

【 摘 要 】

Coronavirus disease-19 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 virus strains has geographical diversity associated with diverse severity, mortality rate, and response to treatment that were characterized using phylogenetic network analysis of SARS-CoV-2 genomes. Although, there is no explicit and integrative explanation for these variations, the genetic arrangement, and stability of SARS-CoV-2 are basic contributing factors to its virulence and pathogenesis. Hence, understanding these features can be used to predict the future transmission dynamics of SARS-CoV-2 infection, drug development, and vaccine. In this review, we discuss the most recent findings on the mutations in the SARS-CoV-2, which provide valuable information on the genetic diversity of SARS-CoV-2, especially for DNA-based diagnosis, antivirals, and vaccine development for COVID-19.

【 授权许可】

Unknown