Costus root extract improves testicular toxicity of Bisphenol A in adult male albino rats: histopathological, ultrastructural and biochemical studies

Beni-Suef University Journal of Basic and Applied Sciences

卷:11

Hosam-Eldin Hussein Osman¹  Rasha R. Salem²  Doaa Galal ELSahra³  Ayman El-Meghawry El-Kenawy⁴  Amin A. Alamin⁴ 

[1] Anatomy Department, College of Medicine, Taif University;

[2] Department of Anatomy, Faculty of Medicine, Alexandria University;

[3] Modern Technology and Information University;

[4] Pathology Department, College of Medicine, Taif University;

关键词: Bisphenol A;    Costus root extract;    Oxidative stress;    Toxicity;    Testes;   

DOI  :  10.1186/s43088-022-00225-z

来源: DOAJ

【 摘 要 】

Abstract Background Bisphenol A (BPA) causes environmental pollution and is used as a natural antioxidant to protect against chemical side-effects. Costus is a well-known medicinal plant containing several biologically active compounds. We investigated the protective effects of costus extract against the toxic effects of BPA in the rat testes. Results Biochemical and immunohistochemical investigations revealed that bisphenol reduced the activity of antioxidant enzymes and plasma testosterone levels and significantly increased P53. Co-administration of costus root extract with BPA improved the depletion of antioxidant enzymes, returned testosterone to normal levels, and improved P53 alternations. Histological and ultrastructural examinations showed that BPA reduced body and testicular weights, and the degeneration of seminiferous tubule germ cells, and the use of costus root extract with BPA attenuated these toxic effects. Conclusions Costus protects rat testes against the toxic effects of BPA.

【 授权许可】

Unknown