The effect of exercise on cytokines: implications for musculoskeletal health: a narrative review

BMC Sports Science, Medicine and Rehabilitation

Sophie Docherty¹  Rachael Harley¹  Stefan Siebert¹  Neal L. Millar¹  Lindsay A. N. Crowe¹  Joseph J. McAuley¹  Paul D. Kirwan²  Carles Pedret³ 

[1] Institute of Infection, Immunity and Inflammation, College of Medicine, Veterinary and Life Sciences, University of Glasgow, 120 University Avenue, G12 8TA, Glasgow, Scotland, UK;School of Physiotherapy, Royal College of Surgeons in Ireland, Dublin, Ireland;Physiotherapy Department, Connolly Hospital, Dublin, Ireland;Sports Medicine and Imaging Department, Clinica Diagonal, C/Sant Mateu 24-26, 08950, Esplugues de Llobregat, Spain;

关键词: Exercise;    Cytokines;    Osteoarthritis;    Tendinopathy;    Inflammation;   

DOI  :  10.1186/s13102-022-00397-2

来源: Springer

【 摘 要 】

The physiological effects of physical exercise are ubiquitously reported as beneficial to the cardiovascular and musculoskeletal systems. Exercise is widely promoted by medical professionals to aid both physical and emotional wellbeing; however, mechanisms through which this is achieved are less well understood. Despite numerous beneficial attributes, certain types of exercise can inflict significant significant physiological stress. Several studies document a key relationship between exercise and immune activation. Activation of the innate immune system occurs in response to exercise and it is proposed this is largely mediated by cytokine signalling. Cytokines are typically classified according to their inflammatory properties and evidence has shown that cytokines expressed in response to exercise are diverse and may act to propagate, modulate or mitigate inflammation in musculoskeletal health. The review summarizes the existing literature on the relationship between exercise and the immune system with emphasis on how exercise-induced cytokine expression modulates inflammation and the immune response.

【 授权许可】

CC BY