Intestinal dysbiosis featuring abundance of Streptococcus associates with Henoch-Schönlein purpura nephritis (IgA vasculitis with nephritis) in adult

BMC Nephrology

Yi Tang¹  Wei Qin¹  Jiaxing Tan²  Zhengxia Zhong³ 

[1] West China Hospital, Sichuan University, Chengdu, Sichuan, China;West China Hospital, Sichuan University, Chengdu, Sichuan, China;West China School of Medicine, Sichuan University, Chengdu, Sichuan, China;West China Hospital, Sichuan University, Chengdu, Sichuan, China;West China School of Medicine, Sichuan University, Chengdu, Sichuan, China;Affiliated Hospital of Zunyi Medical University, Guizhou, China;

关键词: Henoch-Schönlein purpura nephritis (HSPN);    Gut microbiota;    Streptococcus;   

DOI  :  10.1186/s12882-021-02638-x

来源: Springer

【 摘 要 】

BackgroundThe pathogenesis of Henoch-Schönlein purpura nephritis (HSPN) is closely associated with mucosal infection. But whether intestinal microbiota dysbiosis plays a role in it is not clear.MethodsA total of 52 participants including 26 HSPN patients and 26 healthy controls were included. By using 16S ribosomal RNA gene sequencing, the intestinal microbiota composition between HSPN and healthy controls was compared. The diagnostic potency was evaluated by Receiver operating characteristic (ROC) with area under curves (AUC). Meanwhile, correlation analysis was also performed.ResultsThe lower community richness and diversity of fecal microbiota was displayed in HSPN patients and the structure of gut microbiota was remarkedly different. A genus-level comparison indicated a significant increase in the proportions of g-Bacteroides, g-Escherichia–Shigella and g-Streptococcus, and a marked reduction of g-Prevotella_9 in HSPN patients, suggesting that the overrepresentation of potential pathogens and reduction of profitable strains were the main feature of the dysbiosis. The differential taxonomic abundance might make sense for distinguishing HSPN from healthy controls, with AUC of 0.86. The relative abundance of the differential bacteria was also concerned with clinical indices. Among them, Streptococcus spp. was positively associated with the severity of HSPN (P < 0.050). It was found that HSPN patients with higher level of Streptococcus spp. were more likely to suffering from hematuria and hypoalbuminemia (P < 0.050).ConclusionsThe dysbiosis of gut microbiota was obvious in HSPN patients, and the intestinal mucosal streptococcal infection was distinctive, which was closely related to its severity.

【 授权许可】

CC BY