Helicobacter pylori cagA status and gastric mucosa-associated lymphoid tissue lymphoma: a systematic review and meta-analysis

Journal of Health, Population and Nutrition

Amirhossein Sahebkar¹  Yoshio Yamaoka²  Mohsen Karbalaei³  Masoud Keikha⁴ 

[1] Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran;Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran;Department of Environmental and Preventive Medicine, Faculty of Medicine, Oita University, Yufu, Oita, Japan;Global Oita Medical Advanced Research Center for Health, Oita University, Yufu, Oita, Japan;Department of Microbiology and Virology, School of Medicine, Jiroft University of Medical Sciences, Jiroft, Iran;Department of Microbiology and Virology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;

关键词: CagA antigen;    Gastric MALT lymphoma;    Helicobacter pylori;    Meta-analysis;   

DOI  :  10.1186/s41043-021-00280-9

来源: Springer

【 摘 要 】

BackgroundRecent studies have investigated the role of Helicobacter pylori infection in the development of gastric mucosa-associated lymphoid tissue (MALT) lymphoma. It is estimated that approximately 0.1% of people infected with H. pylori develop gastric MALT lymphoma. However, the role of the CagA antigen, the highest causative agent of H. pylori, in increasing the risk of gastric MALT lymphoma remains unclear and controversial. A systematic review and meta-analysis were conducted to evaluate the effect of cagA status on the development of gastric MALT lymphoma.MethodsAll articles evaluating the status of the cagA gene in the development of gastric MALT lymphoma were collected using systematic searches in online databases, including PubMed, Scopus, Embase, and Google Scholar, regardless of publication date. The association between cagA and gastric MALT lymphoma was assessed using the odds ratio (OR) summary. In addition, a random-effects model was used in cases with significant heterogeneity.ResultsA total of 10 studies met our inclusion criteria, among which 1860 patients participated. No association between cagA status and the development of MALT lymphoma (extranodal marginal zone B-cell lymphoma) was found in this study (OR 1.30; 0.906–1.866 with 95% CIs; I2: 45.83; Q-value: 12.92). Surprisingly, a meaningful association was observed between cagA status and diffuse large B-cell lymphoma (OR 6.43; 2.45–16.84 with 95% CIs). We also observed an inverse association between vacA and gastric MALT lymphoma risk (OR 0.92; 0.57–1.50 with 95% CIs).ConclusionsIt seems that the infection with cagA-positive H. pylori strains does not have a meaningful effect on the gastric MALT lymphoma formation, while translocated CagA antigen into the B cells plays a crucial role in the development of diffuse large B-cell lymphoma.

【 授权许可】

CC BY