Glutathione peroxidase level in patients with Helicobacter pylori-associated gastritis

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Tala, Z.Z.^1 ; Siregar, G.A.^2 ; Siregar, G.P.^3

Department of Nutrition, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia^1

Division of Gastroentero-Hepatology, Department of Internal Medicine, Universitas Sumatera Utara, Haji Adam Malik General Hospital, Medan, Indonesia^2

Division of Urology, Department of Surgery, Universitas Sumatera Utara, Haji Adam Malik General Hospital, Medan, Indonesia^3

关键词: Antioxidative defense systems;    Bivariate analysis;    Cross-sectional study;    Glutathione peroxidase;    Helicobacter pylori;    Helicobacter pylori (H. pylori);    Mann-Whitney U test;    Reactive oxygen species;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012058/pdf
DOI  :  10.1088/1755-1315/125/1/012058

来源: IOP

【 摘 要 】

Helicobacter pylori (H. pylori) associated with the generation of reactive oxygen species (ROS), with leads to oxidative stress in the gastric mucosa. GPX is one of human antioxidative defense system allows the elimination of excess ROS. A cross-sectional study was in 80 consecutive gastritis patients who came to the endoscopic unit of Adam Malik General Hospital and PermataBunda Hospital in Medan, Indonesia, from May-September 2017, to determine the difference of GPX serum level between positive and negative infected H. pylori. the diagnosis of gastritis used Histopathology. Rapid urease test for diagnosis of H. pylori infection. Serum samples were obtained to determined circulating GPX. It used Univariate and bivariate analysis (Mann Whitney U test). There were 50 patients (62.5%) infected with H. pylori. GPX levels in patients with positive H. pylori gastritis were lower than those of negative H. pylori but did not differ significantly. In conclusion, there were no significant differences in GPX level between positive and negative infected H. pylori patients.