Association of Helicobacter pylori infection with the risk of metabolic syndrome and insulin resistance: an updated systematic review and meta-analysis

Diabetology & Metabolic Syndrome

Hamid Reza Baradaran¹  Lotfolah Saed²  Farhad Moradpour³  Yousef Moradi⁴  Parisa Kohnepoushi⁵  Asra Moradkhani⁵  Mobin Azami⁵  Hojat Dehghanbanadaki⁶ 

[1] Ageing Clinical & Experimental Research Team, Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK;Endocrine Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Sanandaj, Iran;Department of Endocrinology, Faculty of Medicine, Kurdistan University of Medical Science, Sanandaj, Iran;Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Science, Sanandaj, Iran;Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Science, Sanandaj, Iran;Department of Biostatics and Epidemiology, Faculty of Medicine, Kurdistan University of Medical Science, Sanandaj, Iran;Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran;Students Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran;

关键词: Helicobacter pylori;    Insulin resistance;    Metabolic syndrome;    Systematic review;    Meta-analysis;   

DOI  :  10.1186/s13098-021-00765-x

来源: Springer

【 摘 要 】

BackgroundConflicting results of recent studies on the association between Helicobacter pylori (H. pylori) infection and the risk of insulin resistance and metabolic syndrome explored the need for updated meta-analysis on this issue. Therefore, this systematic review aimed to estimate the pooled effect of H. pylori infection on the risk of insulin resistance and metabolic syndrome.MethodsTo identify case–control studies and cohort studies evaluating the association of H. pylori infection with insulin resistance and metabolic syndrome, a comprehensive literature search was performed from international databases including Medline (PubMed), Web of Sciences, Scopus, EMBASE, and CINHAL from January 1990 until January 2021. We used odds ratio with its 95% confidence interval to quantify the effect of case–control studies and risk ratio with its 95% CI for the effect of cohort studies.Results22 studies with 206,911 participants were included for meta-analysis. The pooled estimate of odds ratio between H. pylori infection and metabolic syndrome in case–control studies was 1.19 (95% CI 1.05–1.35; I2 = 0%), and in cohort studies, the pooled risk ratio was 1.31 (95% CI 1.13–1.51; I2 = 0%). Besides, case–control studies showed the pooled odds ratio of 1.54 (95% CI 1.19–1.98; I2 = 6.88%) for the association between H. pylori infection and insulin resistance.ConclusionIn this meta-analysis, the results showed that there was a possibility of metabolic syndrome and insulin resistance in case of H. pylori infection.

【 授权许可】

CC BY