Molecular Medicine | |
Risk surveillance and mitigation: autoantibodies as triggers and inhibitors of severe reactions to SARS-CoV-2 infection | |
Ivo Mueller1  Aisah Amelia1  George W. Ashdown1  Emily M. Eriksson1  Catherine Chen1  Anna K. Coussens2  | |
[1] The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, VIC, Australia;Department of Medical Biology, The University of Melbourne, 3052, Melbourne, VIC, Australia;The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, 3052, Parkville, VIC, Australia;Department of Medical Biology, The University of Melbourne, 3052, Melbourne, VIC, Australia;Department of Pathology, Institute of Infectious Disease and Molecular Medicine, Wellcome Centre for Infectious Diseases Research in Africa, University of Cape, Cape Town, South Africa; | |
关键词: Autoantibodies; SARS-CoV-2; COVID-19; Autoimmunity; | |
DOI : 10.1186/s10020-021-00422-z | |
来源: Springer | |
【 摘 要 】
COVID-19 clinical presentation differs considerably between individuals, ranging from asymptomatic, mild/moderate and severe disease which in some cases are fatal or result in long-term effects. Identifying immune mechanisms behind severe disease development informs screening strategies to predict who are at greater risk of developing life-threatening complications. However, to date clear prognostic indicators of individual risk of severe or long COVID remain elusive. Autoantibodies recognize a range of self-antigens and upon antigen recognition and binding, important processes involved in inflammation, pathogen defence and coagulation are modified. Recent studies report a significantly higher prevalence of autoantibodies that target immunomodulatory proteins including cytokines, chemokines, complement components, and cell surface proteins in COVID-19 patients experiencing severe disease compared to those who experience mild or asymptomatic infections. Here we discuss the diverse impacts of autoantibodies on immune processes and associations with severe COVID-19 disease.
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
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RO202203049744878ZK.pdf | 3339KB | download |