Effect of mineral excipients on processing traditional Chinese medicines: an insight into the components, pharmacodynamics and mechanism

Chinese Medicine

Aijing Leng¹  Yan Liu¹  Jialin Qu²  Xiaojie Li³  Cai Chen⁴ 

[1] Department of Traditional Chinese Medicine, The First Affiliated Hospital of Dalian Medical University, No. 222, Zhongshan Road, 116011, Dalian, China;Institute (College) of Pharmacy, Dalian Medical University, No. 9, South Road of Lvshun, 116044, Dalian, China;Institute (College) of Pharmacy, Dalian Medical University, No. 9, South Road of Lvshun, 116044, Dalian, China;Clinical Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, No. 222, Zhongshan Road, 116011, Dalian, China;Institute (College) of Pharmacy, Dalian Medical University, No. 9, South Road of Lvshun, 116044, Dalian, China;Institute (College) of Integrative Medicine, Dalian Medical University, No. 9, South Road of Lvshun, 116044, Dalian, China;

关键词: Mineral excipients;    Processing;    Traditional Chinese medicine (TCM);    Components;    Pharmacodynamics;    Mechanism;   

DOI  :  10.1186/s13020-021-00554-8

来源: Springer

【 摘 要 】

Traditional Chinese medicines are an important class of natural products mainly derives from animals, plants and minerals, most of which need to be improved and processed before clinical use due to their own hard texture, impurities or toxicity. As an important part of solid excipients, mineral excipients that contain some metal elements play indispensable and unique roles in the pretreatment process of traditional Chinese medicine. However, deficiency of holistic understanding of the effect of mineral excipients hinders their application and development. This article reviews several mineral excipients including alumen, talci pulvis, soil, soda lime, halloysitum rubrum and cinnabaris systemically. Their processing significance on traditional Chinese medicines were revealed from components, pharmacodynamics and mechanism aspects. Furthermore, prospect and problems including processing technologies, quality standards of mineral excipients and processing mechanism were put forward. This review supply comprehensive information for better and scientific usage of mineral excipients in processing traditional Chinese medicines.

【 授权许可】

CC BY