Immune cell targeting nanoparticles: a review

Biomaterials Research

Na Kyeong Lee¹  Chun Gwon Park²  Se-Na Kim³ 

[1] Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, 16419, Suwon, Gyeonggi, Republic of Korea;Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, 16419, Suwon, Gyeonggi, Republic of Korea;Department of Biomedical Engineering, SKKU Institute for Convergence, Sungkyunkwan University (SKKU), 16419, Suwon, Gyeonggi, Republic of Korea;Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, 16419, Suwon, Gyeonggi, Republic of Korea;Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), 16419, Suwon, Gyeonggi, Republic of Korea;Institute of Medical & Biological Engineering, Medical Research Center, Seoul National University, 03080, Seoul, Republic of Korea;

关键词: Target drug delivery;    Nanoparticles;    Surface modification;    Immune cells;    Active targeting;    Target ligand;    Enzymatic response;   

DOI  :  10.1186/s40824-021-00246-2

来源: Springer

【 摘 要 】

Immune cells are attractive targets for therapy as they are direct participants in a variety of diseases. Delivering a therapeutic agent only to cells that act on a disease by distinguishing them from other cells has the advantage of concentrating the therapeutic effect and lowering systemic side effects. Distinguishing each immune cell from other immune cells to deliver substances, including drugs and genes, can be achieved using nanotechnology. And also nanoparticles can ensure in vivo stability and sustained drug release. In addition, there is an ease of surface modification, which is an important characteristic that can be utilized in targeted drug delivery systems. This characteristic allows us to utilize various properties that are specifically expressed in each immune cell. A number of studies have delivered various substances specifically to immune cells through surface engineering with active target ligands that can target each immune cell and enzyme-responsive coating, and demonstrated high therapeutic effects compared to conventional treatments. Progress in research on target delivery has been suggested to be a breakthrough for the treatments of various diseases, including cancer treatment.

【 授权许可】

CC BY