Adverse events of inactivated COVID-19 vaccine in HIV-infected adults

AIDS Research and Therapy

Shi Zou¹  Mengmeng Wu¹  Songjie Wu²  Ke Liang³  Wei Guo⁴  Weiming Tang⁵  Fangzhao Ming⁶  Yubin Zhang⁶ 

[1] Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China;Department of Nosocomial Infection Management, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China;Department of Nosocomial Infection Management, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China;Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, China;Wuhan Research Center for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan, China;Center of Preventing Mother-To-Child Transmission for Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China;Department of Nosocomial Infection Management, Department of Infectious DiseasesCenter of Preventing Mother-To-Child Transmission for Infectious Diseases, Wuhan Research Center for Infectious Diseases and CancerChinese Academy of Medical Sciences, Zhongnan Hospital of Wuhan University, 430071, Wuhan, China;Department of Pathology, Zhongnan Hospital of Wuhan University, Wuhan, China;Department of Pathology, School of Basic Medical Sciences, Wuhan University, Wuhan, China;Guangdong No. 2 Provincial People’s Hospital, University of North Carolina at Chapel Hill Project-China, 510095, Guangzhou, China;The University of North Carolina at Chapel Hill Project-China, Guangzhou, China;Wuchang District Center for Disease Control and Prevention, Wuhan, Hubei, China;

关键词: People living with HIV(PLWH);    COVID-19;    Inactivated vaccine;    Adverse event;   

DOI  :  10.1186/s12981-021-00416-1

来源: Springer

【 摘 要 】

This study aims to evaluate the safety of inactivated COVID-19 vaccine among adult people living with HIV (PLWH). In total, 259 PLWH who received at least one dose of inactivated COVID-19 vaccine were enrolled, and post-vaccination adverse events (AEs) were evaluated seven days following each vaccination dose. The overall AE frequency was 22.8% after dose one, which was higher than after dose two (10.2%) (P < 0.001). No severe side event or vaccine safety concern was observed. Our finding was essential in reducing vaccine hesitancy among PLWH.

【 授权许可】

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