The gut hormone glucose-dependent insulinotropic polypeptide is downregulated in response to myocardial injury

Cardiovascular Diabetology

Julia Moellmann¹  Matthias Rau¹  Robert W. Mertens¹  Nikolaus Marx¹  Jörg Schröder¹  Paul Idel¹  Maria C. Arrivas¹  Florian Kahles¹  Michael Lehrke²  Martin Reugels³  Ann C. Foldenauer⁴  Emiel P. C. van der Vorst⁵ 

[1] Department of Internal Medicine I-Cardiology, University Hospital Aachen, Pauwelsstraße 30, 52074, Aachen, Germany;Department of Internal Medicine I-Cardiology, University Hospital Aachen, Pauwelsstraße 30, 52074, Aachen, Germany;Department of Internal Medicine, University Hospital Aachen, Pauwelsstraße 30, 52074, Aachen, Germany;Department of Medical Statistics, University Hospital Aachen, Pauwelsstraße 19, 52074, Aachen, Germany;Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, 60596, Frankfurt am Main, Germany;Interdisciplinary Center for Clinical Research (IZKF), Institute for Molecular Cardiovascular Research (IMCAR), University Hospital Aachen, Pauwelsstraße 30, 52074, Aachen, Germany;Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Universiteitssingel 50, 6229 ER, Maastricht, The Netherlands;Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University Munich, Pettenkoferstraße 9, 80336, Munich, Germany;

关键词: Incretin;    GIP;    Myocardial infarction;    Cardiac surgery;    Cardiac injury;   

DOI  :  10.1186/s12933-022-01454-3

来源: Springer

【 摘 要 】

BackgroundThe gut incretin hormones GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic peptide) are secreted by enteroendocrine cells following food intake leading to insulin secretion and glucose lowering. Beyond its metabolic function GIP has been found to exhibit direct cardio- and atheroprotective effects in mice and to be associated with cardiovascular prognosis in patients with myocardial infarction. The aim of this study was to characterize endogenous GIP levels in patients with acute myocardial infarction.Methods and resultsSerum concentrations of GIP were assessed in 731 patients who presented with clinical indication of coronary angiography. Circulating GIP levels were significantly lower in patients with STEMI (ST-elevation myocardial infarction; n=100) compared to clinically stable patients without myocardial infarction (n=631) (216.82 pg/mL [Q1–Q3: 52.37–443.07] vs. 271.54 pg/mL [Q1–Q3: 70.12–542.41], p = 0.0266). To characterize endogenous GIP levels in patients with acute myocardial injury we enrolled 18 patients scheduled for cardiac surgery with cardiopulmonary bypass and requirement of extracorporeal circulation as a reproducible condition of myocardial injury. Blood samples were drawn directly before surgery (baseline), upon arrival at the intensive care unit (ICU), 6 h post arrival to the ICU and at the morning of the first and second postoperative days. Mean circulating GIP concentrations decreased in response to surgery from 45.3 ± 22.6 pg/mL at baseline to a minimum of 31.9 ± 19.8 pg/mL at the first postoperative day (p = 0.0384) and rose again at the second postoperative day (52.1 ± 28.0 pg/mL).ConclusionsCirculating GIP levels are downregulated in patients with myocardial infarction and following cardiac surgery. These results might suggest nutrition-independent regulation of GIP secretion following myocardial injury in humans.

【 授权许可】

CC BY