The roles of Eph receptors, neuropilin-1, P2X7, and CD147 in COVID-19-associated neurodegenerative diseases: inflammasome and JaK inhibitors as potential promising therapies

Cellular & Molecular Biology Letters

Hamidreza Zalpoor¹  Majid Khoshmirsafa²  Azam Samei³  Majid Pornour⁴  Hossein Aazami⁵  Fatemeh Heidari⁶  Razieh Forghaniesfidvajani⁷  Abdullatif Akbari⁷  Farhad Seif⁸  Monireh Kamali⁹  Shirin Manshouri⁹  Azadeh Afzalnia⁹ 

[1] American Association of Kidney Patients, Tampa, FL, USA;Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran;Shiraz Neuroscience Research Center, Shiraz University of Medical Sciences, Shiraz, Iran;Department of Immunology, School of Medicine, Iran University of Medical Sciences, Iran, Iran;Department of Laboratory Sciences, School of Paramedical Sciences, Kashan University of Medical Sciences, Kashan, Iran;Department of Oncology, School of Medicine, University of Maryland, Maryland, USA;Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran;Immunology Department, Faculty of Medicine, Tarbiat Modares University, Tehran, Iran;Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran;Neuroscience Research Center, Iran University of Medical Sciences, Tehran, Iran;Department of Immunology and Allergy, Academic Center for Education, Culture, and Research (ACECR), Enghelab St., Aboureyhan St., Vahid Nazari Crossroad, P17, 1315795613, Tehran, Iran;Rajaei Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran;

关键词: COVID-19;    CNS;    Ephrin;    Neuropilin-1;    P2X7;    CD147;    Cytokine;    Jak;    Inflammasome;    Neurodegenerative diseases;    Alzheimer’s disease;    Parkinson’s disease;   

DOI  :  10.1186/s11658-022-00311-1

来源: Springer

【 摘 要 】

The novel coronavirus disease 2019 (COVID-19) pandemic has spread worldwide, and finding a safe therapeutic strategy and effective vaccine is critical to overcoming severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Therefore, elucidation of pathogenesis mechanisms, especially entry routes of SARS-CoV-2 may help propose antiviral drugs and novel vaccines. Several receptors have been demonstrated for the interaction of spike (S) protein of SARS-CoV-2 with host cells, including angiotensin-converting enzyme (ACE2), ephrin ligands and Eph receptors, neuropilin 1 (NRP-1), P2X7, and CD147. The expression of these entry receptors in the central nervous system (CNS) may make the CNS prone to SARS-CoV-2 invasion, leading to neurodegenerative diseases. The present review provides potential pathological mechanisms of SARS-CoV-2 infection in the CNS, including entry receptors and cytokines involved in neuroinflammatory conditions. Moreover, it explains several neurodegenerative disorders associated with COVID-19. Finally, we suggest inflammasome and JaK inhibitors as potential therapeutic strategies for neurodegenerative diseases.

【 授权许可】

CC BY