Journal of Nanobiotechnology | |
A novel small diameter nanotextile arterial graft is associated with surgical feasibility and safety and increased transmural endothelial ingrowth in pig | |
Raimondo Ascione1  Nadiah Sulaiman1  Thomas W. Johnson1  Sarah Jane George1  Alexander Ward1  Vito Domenico Bruno1  John Joseph2  Helna Mary Baby3  Deepthy Menon3  Shantikumar V. Nair3  | |
[1] Bristol Heart Institute and Translational Biomedical Research Centre, Faculty of Health Science, University of Bristol, BS2 8HW, Bristol, UK;Bristol Heart Institute and Translational Biomedical Research Centre, Faculty of Health Science, University of Bristol, BS2 8HW, Bristol, UK;Centre for Nanosciences & Molecular Medicine, Amrita Vishwa Vidyapeetham, 682 041, Kochi, India;Centre for Nanosciences & Molecular Medicine, Amrita Vishwa Vidyapeetham, 682 041, Kochi, India; | |
关键词: Nanotextile; Small diameter vascular grafts; Endothelialisation; Nanofibers; Electrospinning; In-vivo feasibility; Coronary surgery; Vascular surgery; Nanotextile vascular prosthesis; Vascular graft failure; Tissue engineering; | |
DOI : 10.1186/s12951-022-01268-1 | |
来源: Springer | |
【 摘 要 】
Globally, millions of patients are affected by myocardial infarction or lower limb gangrene/amputation due to atherosclerosis. Available surgical treatment based on vein and synthetic grafts provides sub-optimal benefits. We engineered a highly flexible and mechanically robust nanotextile-based vascular graft (NanoGraft) by interweaving nanofibrous threads of poly-L-lactic acid to address the unmet need. The NanoGrafts were rendered impervious with selective fibrin deposition in the micropores by pre-clotting. The pre-clotted NanoGrafts (4 mm diameter) and ePTFE were implanted in a porcine carotid artery replacement model. The fibrin-laden porous milieu facilitated rapid endothelization by the transmural angiogenesis in the NanoGraft. In-vivo patency of NanoGrafts was 100% at 2- and 4-weeks, with no changes over time in lumen size, flow velocities, and minimal foreign-body inflammatory reaction. However, the patency of ePTFE at 2-week was 66% and showed marked infiltration, neointimal thickening, and poor host tissue integration. The study demonstrates the in-vivo feasibility and safety of a thin-layered vascular prosthesis, viz., NanoGraft, and its potential superiority over the commercial ePTFE.Graphical Abstract
【 授权许可】
CC BY
【 预 览 】
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