Comparative Study of the Physical, Topographical and Biological Properties of Electrospinning PCL, PLLA, their Blend and Copolymer Scaffolds

International Conference on Nanomaterials and Biomaterials 2017

材料科学;物理学;生物科学

Bolbasov, E.^1 ; Goreninskii, S.^1 ; Tverdokhlebov, S.^1 ; Mishanin, A.^2 ; Viknianshchuk, A.^3 ; Bezuidenhout, D.^4 ; Golovkin, A.^2

National Research Tomsk Polytechnic University, 30 Lenin av, Tomsk

634050, Russia^1

Almazov National Medical Research Centre, 2 Akkuratova str, St.-Petersburg

197341, Russia^2

Saint Petersburg University, 13B Universitetskaya Emb, St.-Petersburg

199034, Russia^3

University of Cape Town, 203 Cape Heart Centre, Anzio Road, Observatory, Cape Town

7925, South Africa^4

关键词: Biofunctionalization;    Biological properties;    Comparative studies;    Manufacturing process;    Material characteristics;    Mesenchyme stem cells;    Small diameter vascular grafts;    Topographical properties;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/350/1/012012/pdf
DOI  :  10.1088/1757-899X/350/1/012012

来源: IOP

【 摘 要 】

Biodegradable polymers (blends, copolymers) could be the ideal materials for manufacturing of scaffolds for small diameter vascular graft. Such material characteristics as mechanical properties, chemical structure, nano- and micro topography, surface charge, porosity, wettability etc. are becoming the most important aspects for effectiveness of prosthesis biofunctionalization because of their great impact on cell adhesion, spreading, cell proliferation, differentiation and cell function. The aim of the study is to compare physical, topographical and biological properties of polycaprolactone (PCL), poly-L-lactic acid (PLLA), polycaprolactone + poly-L-lactic acid blend (PCL PLLA), L-lactide/Caprolactone copolymer (PLC7015) scaffolds fabricated with the same fiber thickness using electrospun technology. PCL PLLA scaffolds had the highest average pore area (p