Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species

Frontiers in Cellular and Infection Microbiology

Yuanyuan Yang¹  Kejia Ma¹  Kai Nie¹  Zhenyu Yang¹  Ting Tong¹  Weiwei Luo¹  Zhaohua Shen¹  Xiaoyan Wang¹  Mengwei Xiao¹ 

[1] Department of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, China;Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Cancer Research Institute, Central South University, Changsha, China;

关键词: Roseburia;    Roseburia intestinalis;    probiotic;    inflammatory bowel disease (IBD);    microbiome;   

DOI  :  10.3389/fcimb.2021.757718

来源: Frontiers

【 摘 要 】

Roseburia intestinalis is an anaerobic, Gram-positive, slightly curved rod-shaped flagellated bacterium that produces butyrate in the colon. R. intestinalis has been shown to prevent intestinal inflammation and maintain energy homeostasis by producing metabolites. Evidence shows that this bacterium contributes to various diseases, such as inflammatory bowel disease, type 2 diabetes mellitus, antiphospholipid syndrome, and atherosclerosis. This review reveals the potential therapeutic role of R. intestinalis in human diseases. Patients with inflammatory bowel disease exhibit significant changes in R. intestinalis abundance, and they may benefit a lot from modulations targeting R. intestinalis. The data reviewed here demonstrate that R. intestinalis plays its role in regulating barrier homeostasis, immune cells, and cytokine release through its metabolite butyrate, flagellin and other. Recent advancements in the application of primary culture technology, culture omics, single-cell sequencing, and metabonomics technology have improved research on Roseburia and revealed the benefits of this bacterium in human health and disease treatment.

【 授权许可】

CC BY