Interleukin-19 Is a Negative Regulator of Innate Immunity and Critical for Colonic Protection

Journal of Pharmacological Sciences

Andrew J. Murphy¹  Yukiko Matsuo²  Margaret Karow¹  George D. Yancopoulos¹  Hidemitsu Nakajima²  David M. Valenzuela¹  Yasu-Taka Azuma²  Tadayoshi Takeuchi² 

[1] Regeneron Pharmaceuticals, Inc., USA;Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Science, Japan

关键词: interleukin-19;    inflammatory bowel disease (IBD);    colonic inflammation;    macrophages;    cytokine;   

DOI  :  10.1254/jphs.10R02CR

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(50)Cited-By(14)The cytokine, interleukin (IL)-19, is a member of the IL-10 family that includes IL-20, IL-22, IL-24, and IL-26. Recent studies have shown that IL-19 is produced by keratinocytes, epithelial cells, macrophages, and B-cells. Little is known about the exact biological role of IL-19 in immunological regulation, although there is an increasing body of data demonstrating that IL-19 is associated with the development of Th2 responses and the pathogenesis of psoriasis. In this review, I shall attempt to discuss current knowledge about the role of IL-19 on macrophages and the potential role in inflammatory bowel disease.

【 授权许可】

Unknown