期刊论文详细信息
Journal of Pharmacological Sciences
Interleukin-19 Is a Negative Regulator of Innate Immunity and Critical for Colonic Protection
Andrew J. Murphy1  Yukiko Matsuo2  Margaret Karow1  George D. Yancopoulos1  Hidemitsu Nakajima2  David M. Valenzuela1  Yasu-Taka Azuma2  Tadayoshi Takeuchi2 
[1] Regeneron Pharmaceuticals, Inc., USA;Laboratory of Veterinary Pharmacology, Division of Veterinary Science, Osaka Prefecture University Graduate School of Life and Environmental Science, Japan
关键词: interleukin-19;    inflammatory bowel disease (IBD);    colonic inflammation;    macrophages;    cytokine;   
DOI  :  10.1254/jphs.10R02CR
学科分类:药学
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society
PDF
【 摘 要 】

References(50)Cited-By(14)The cytokine, interleukin (IL)-19, is a member of the IL-10 family that includes IL-20, IL-22, IL-24, and IL-26. Recent studies have shown that IL-19 is produced by keratinocytes, epithelial cells, macrophages, and B-cells. Little is known about the exact biological role of IL-19 in immunological regulation, although there is an increasing body of data demonstrating that IL-19 is associated with the development of Th2 responses and the pathogenesis of psoriasis. In this review, I shall attempt to discuss current knowledge about the role of IL-19 on macrophages and the potential role in inflammatory bowel disease.

【 授权许可】

Unknown   

【 预 览 】
附件列表
Files Size Format View
RO201911300045489ZK.pdf 456KB PDF download
  文献评价指标  
  下载次数:3次 浏览次数:32次