Curcumin and Inflammatory Bowel Disease: Potential and Limits of Innovative Treatments

Molecules

Liza Vecchi Brumatti²  Annalisa Marcuzzi²  Paola Maura Tricarico¹  Valentina Zanin²  Martina Girardelli²  Anna Monica Bianco²  Bharat B. Aggarwal³ 

[1] Department of Medicine and Surgery and Health Sciences, University of Trieste, Piazzale Europa, 1, Trieste 34137, Italy; E-Mail:;Institute for Maternal and Child Health—IRCCS “Burlo Garofolo”—via dell’Istria, 65/1, Trieste 34137, Italy; E-Mails:Institute for Maternal and Child Health—IRCCS “Burlo Garofolo”—via dell’Istria, 65/1, Trieste 34137, Italy;

关键词: curcumin;    inflammatory bowel disease (IBD);    inflammation;    innovative treatments;   

DOI  :  10.3390/molecules191221127

来源: mdpi

【 摘 要 】

Curcumin belongs to the family of natural compounds collectively called curcuminoids and it possesses remarkable beneficial anti-oxidant, anti-inflammatory, anti-cancer, and neuroprotective properties. Moreover it is commonly assumed that curcumin has also been suggested as a remedy for digestive diseases such as inflammatory bowel diseases (IBD), a chronic immune disorder affecting the gastrointestinal tract and that can be divided in two major subgroups: Crohn’s disease (CD) and Ulcerative Colitis (UC), depending mainly on the intestine tract affected by the inflammatory events. The chronic and intermittent nature of IBD imposes, where applicable, long-term treatments conducted in most of the cases combining different types of drugs. In more severe cases and where there has been no good response to the drugs, a surgery therapy is carried out. Currently, IBD-pharmacological treatments are generally not curative and often present serious side effects; for this reason, being known the relationship between nutrition and IBD, it is worthy of interesting the study and the development of new dietary strategy. The curcumin principal mechanism is the suppression of IBD inflammatory compounds (NF-κB) modulating immune response. This review summarizes literature data of curcumin as anti-inflammatory and anti-oxidant in IBD, trying to understand the different effects in CD e UC.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.