Golden Syrian hamster as a model to study cardiovascular complications associated with SARS-CoV-2 infection

eLife

Jyotsna Dandotiya¹  Rajdeep Dalal¹  Srikanth Sadhu¹  Manas Ranjan Tripathy¹  Akshay Binayke¹  Zaigham Abbas Rizvi²  Amit Awasthi²  Guruprasad R Medigeshi³  Sweety Samal³  Tripti Shrivastava³  Amit Kumar Pandey³  Deepak Kumar Rathore³  Sonu Kumar Gupta⁴  Yashwant Kumar⁴  Suruchi Aggarwal⁴  Amit Kumar Yadav⁴  Shailendra Asthana⁴ 

[1] Immuno-biology Lab, Infection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India;Immuno-biology Lab, Infection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India;Immunology Core, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India;Infection and Immunology Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India;Non-communicable Disease Centre, Translational Health Science and Technology Institute, NCR-Biotech Science Cluster, Faridabad, India;

关键词: hamster;    SARS-CoV2;    cardiovascular;    Other;   

DOI  :  10.7554/eLife.73522

来源: eLife Sciences Publications, Ltd

【 摘 要 】

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in the Golden Syrian hamster causes lung pathology that resembles human coronavirus disease (COVID-19). However, extrapulmonary pathologies associated with SARS-CoV-2 infection and post-COVID sequelae remain to be understood. Here, we show, using a hamster model, that the early phase of SARS-CoV-2 infection leads to an acute inflammatory response and lung pathologies, while the late phase of infection causes cardiovascular complications (CVCs) characterized by ventricular wall thickening associated with increased ventricular mass/body mass ratio and interstitial coronary fibrosis. Molecular profiling further substantiated our findings of CVC as SARS-CoV-2-infected hamsters showed elevated levels of serum cardiac troponin I, cholesterol, low-density lipoprotein, and long-chain fatty acid triglycerides. Serum metabolomics profiling of SARS-CoV-2-infected hamsters identified N-acetylneuraminate, a functional metabolite found to be associated with CVC, as a metabolic marker was found to be common between SARS-CoV-2-infected hamsters and COVID-19 patients. Together, we propose hamsters as a suitable animal model to study post-COVID sequelae associated with CVC, which could be extended to therapeutic interventions.

【 授权许可】

CC BY