期刊论文详细信息
Pathology & Oncology Research
Combination of Praziquantel and Aspirin Minimizes Liver Pathology of Hamster Opisthorchis viverrini Infection Associated Cholangiocarcinoma
Songsri Jiraporn3  Wipaporn Ruangjirachuporn1  Wonkchalee Nadchanan1  Nisana Namwat3  Thidarut Boonmars3  Watcharin Loilome3  Pakkayanee Sudsarn4  Pranee Sriraj2  Ratchadawan Aukkanimart2 
[1] Khon Kaen University$$;Khon Kaen University$$Rajamangala University of Technology Isan Sakonnakhon Campus$$;Khon Kaen University$$Khon Kaen University$$;Khon Kaen University$$Burapha University Sakaeo Campus$$
关键词: Syrian hamster;   
DOI  :  10.1007/s12253-015-9967-y
学科分类:生理学与病理学
来源: Springer
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【 摘 要 】

Opisthorchiasis is one of the major risk factors for cholangiocarcinoma (CCA) in northeastern Thailand. An effective drug for killing this parasite is praziquantel. Recently, several reports have shown that with frequent use, praziquantel may itself be a CCA risk and can cause liver cell damage from an immunopathological response after parasite death. Aspirin has many properties including anti-inflammation and anti-cancer. Therefore, we use of aspirin (As) and praziquantel (Pz) to improve hepatobiliary system function in hamsters infected with Opisthorchis viverrini (OV) and or administered N-nitrosodimethylamine (ND). Livers of OVNDAsPz, appeared healthy macroscopically, suggesting slow progression of cholangiocarcinoma evident by extent of fibrosis and bile duct cell proliferation was less than OVND although aggregations of inflammatory cells remained. Proliferating cell nuclear antigen (PCNA), cytokeratin 19 (CK19), and cancer antigen (CA19-9) staining were strongly positive in OVND, but were only slight in OVNDAs. Moreover, OVNDAsPz, appeared a few inflammatory infiltrations, bile duct proliferation, fibrosis and CCA area than the OVNDAs group. Thirty seven point five percent of hamster in this group could not develop CCA. These findings suggest that using aspirin combination with praziquantel treatment can improve the hepatobiliary system after O. viverrini infection and reduce the risk of CCA.

【 授权许可】

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