Novel reverse electrodialysis-driven iontophoretic system for topical and transdermal delivery of poorly permeable therapeutic agents

Drug Delivery

Myoung-Hoon Jang¹  Minwoong Jung¹  Joo-Hyun Song¹  Joon Lee²  Ki-Taek Kim³  Min-Hwan Kim³  Ju-Hwan Park³  Dae-Duk Kim³  Jae-Young Lee⁴  Hyun-Jong Cho⁵  In-Soo Yoon⁶ 

[1] Biosensor Laboratories Inc, Seoul National University, Gwanak-gu, Seoul, Republic of Korea;Biosensor Laboratories Inc, Seoul National University, Gwanak-gu, Seoul, Republic of Korea;School of Chemical and Biological Engineering, Seoul National University, Gwanak-gu, Seoul, Republic of Korea;College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Gwanak-gu, Seoul, Republic of Korea;College of Pharmacy, Chungnam National University, Yuseong-gu, Daejeon, Republic of Korea;College of Pharmacy, Kangwon National University, Chuncheon-si, Gangwon, Republic of Korea;College of Pharmacy, Pusan National University, Geumjeong-gu, Busan, Republic of Kore;

关键词: Reverse electrodialysis;    iontophoresis;    transdermal delivery;    topical delivery;    vitamin C;    hyaluronic acid;    lopinavir;   

DOI  :  10.1080/10717544.2017.1367975

来源: Taylor & Francis

【 摘 要 】

Topical and transdermal drug delivery has great potential in non-invasive and non-oral administration of poorly bioavailable therapeutic agents. However, due to the barrier function of the stratum corneum, the drugs that can be clinically feasible candidates for topical and transdermal delivery have been limited to small-sized lipophilic molecules. Previously, we fabricated a novel iontophoretic system using reverse electrodialysis (RED) technology (RED system). However, no study has demonstrated its utility in topical and/or transdermal delivery of poorly permeable therapeutic agents. In this study, we report the topical delivery of fluorescein isothiocyanate (FITC)–hyaluronic acid (FITC–HA) and vitamin C and the transdermal delivery of lopinavir using our newly developed RED system in the in vitro hairless mouse skin and in vivo Sprague–Dawley rat models. The RED system significantly enhanced the efficiency of topical HA and vitamin C and transdermal lopinavir delivery. Moreover, the efficiency and safety of transdermal delivery using the RED system were comparable with those of a commercial ketoprofen patch formulation. Thus, the RED system can be a potential topical and transdermal delivery system for various poorly bioavailable pharmaceuticals including HA, vitamin C, and lopinavir.

【 授权许可】

CC BY