Transdermal iontophoresis patch with reverse electrodialysis

Drug Delivery

Minyoung Kim¹  Kilsung Kwon¹  Joon Lee²  Joonhong Min³  Won-serk Kim³  Nathaniel S. Hwang⁴ 

[1] Biosensor Laboratories Incoperated, Seoul National University, Seoul, Republic of Korea;Biosensor Laboratories Incoperated, Seoul National University, Seoul, Republic of Korea;School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea, an;Department of Dermatology, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Republic of Kore;School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea, an;

关键词: Reverse electrodialysis;    patch;    iontophoresis;    transdermal;   

DOI  :  10.1080/10717544.2017.1282555

来源: Taylor & Francis

【 摘 要 】

Reverse electrodialysis (RED) technology generates energy from the salinity gradient by contacting waters with different salinity. Herein, we develop the disposable skin patch using this eco-friendly energy. The current density, which can be controlled easily without special circuit, is enough to iontophoretic drug delivery. In vitro study, this iontophoretic system enhanced the transdermal delivery of peptide, which is difficult to penetrate the skin barrier by simple diffusion. We design the disposable iontophoretic skin patch using RED system and suggest this patch can be apply on new cosmetic patch or disposable drug patch.

【 授权许可】

CC BY