Clinical application of mesenchymal stem cells in rheumatic diseases

Stem Cell Research & Therapy

Xingxing Zhao¹  Helin Yang¹  Zewen Wu²  Rong Li²  Liyun Zhang²  Yajing Wang²  Dan Ma²  Baoqi Yang² 

[1] Shanxi University of Chinese Medicine, 030619, Jinzhong, Shanxi, China;Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, 030032, Taiyuan, China;

关键词: Mesenchymal stem cells;    Rheumatic diseases;    Clinical application;   

DOI  :  10.1186/s13287-021-02635-9

来源: Springer

【 摘 要 】

Mesenchymal stem cells (MSCs) are pluripotent stem cells derived from mesoderm during early development that are characterized by high self-renewal ability and multidirectional differentiation potential. These cells are present various tissues in the human body and can be cultured in vitro. Under specific conditions, MSCs can differentiate into osteoblasts, neuron-like cells, adipocytes and muscle cells and so on, therefore, have a great application value in cell replacement therapy and tissue repair. In recent years, the application of MSCs in rheumatic diseases has received increasing attention. On the one hand, MSCs have the ability to differentiate into bone and cartilage cells; on the other hand, these stem cells are also involved in immune regulation, resulting in the alleviation of inflammation and anti-fibrotic properties and the promotion of vascular repair, thus bringing new hope for the treatment of rheumatic diseases. This article reviews the clinical progress in MSC application for the treatment of rheumatic diseases.

【 授权许可】

CC BY