The biocompatibility of titanium alloy or stainless steel internal fixation material combined with anti-tuberculosis drug sustained-release carrier

2019 International Conference on Advanced Materials and Technology for Sustainable Life

Wang, Na^1 ; Guo, Shaoning^1 ; Yang, Kang^2 ; Wang, Jinguo^3

Department of Anesthesiology, First Hospital of Jilin University, China^1

Department of Sports Medicine, First Hospital of Jilin University, China^2

Department of Urology, First Hospital of Jilin University, China^3

关键词: Antituberculosis;    Clinical application;    Developing trend;    Internal fixation;    Multi materials;    Surgical treatment;    Sustained release;    Systemic administration;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/587/1/012002/pdf
DOI  :  10.1088/1757-899X/587/1/012002

来源: IOP

【 摘 要 】

The purpose of this paper is to summarize the treatment of characteristics of bone tuberculosis with titanium alloy or stainless steel internal fixation devices combined with antituberculosis sustained-release materials. A search of literature on the implantation of titanium alloy or stainless steel internal fixation devices combined with anti-tuberculosis sustained-release materials for bone tuberculosis from 1995 to 2019 was performed using PubMed and Web of Science databases. Local sustained-release anti-tuberculosis drugs have been applied in surgical treatment of bone and joint tuberculosis. It can reduce the adverse reactions of systemic administration of a number of anti-tuberculosis drugs in patients with bone tuberculosis and continuously achieve the local effective anti-tuberculosis effect. At present, there are many kinds of materials used in drug sustained-release materials, each of which has its own advantages and disadvantages. It is difficult to achieve the ideal effect of antituberculosis and bone repair. Different materials can be used together to make up the disadvantages for each other. The further progress towards ideal biological materials can be achieved. It may be the developing trend of clinical application of multi-material composite as sustained-release carrier against tuberculosis.