Design, Synthesis and Study of Antibacterial and Antitubercular Activity of Quinoline Hydrazone Hybrids

Heterocyclic communications

article

Shruthi T G¹  Sangeetha Subramanian²  Sumesh Eswaran¹ 

[1] Ltd.;Vellore Institute of Technology

关键词: Quinoline;    Hydrazone;    Antituberculosis;    Antibacterial activity;    Cytotoxicity;   

DOI  :  10.1515/hc-2020-0109

学科分类：内科医学

来源: De Gruyter

【 摘 要 】

Emerging bacterial resistance is causing widespread problems for the treatment of various infections. Therefore, the search for antimicrobials is a never-ending task. Hydrazones and quinolines possess a wide variety of biological activities. Herewith, eleven quinoline hydrazone derivatives have been designed, synthesized, characterized and evaluated for their antibacterial activity and antitubercular potential against Mtb WT H37Rv. Compounds QH-02 , QH-04 and QH-05 were found to be promising compounds with an MIC value of 4 μg/mL against Mtb WT H37Rv. Compounds QH-02 , QH-04 , QH-05 , and QH-11 were also found to be active against bacterial strains including Acinetobacter baumanii, Escherichia coli and Staphylococcus aureus . Further, we have carried out experiments to confirm the cytotoxicity of the active compounds and found them to be non-toxic.

【 授权许可】

CC BY|CC BY-NC-ND